Granulator Machine
A granulator machine is essential for transforming fine powders into uniform granules, a critical step in pharmaceutical manufacturing. Designed for precision, a granulator machine for pharmaceuticals ensures optimal particle size and consistency for tablets and capsules. Advanced granulators deliver efficiency and reliability, meeting the stringent demands of the industry. For detailed specifications and additional information, please contact us.
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Choosing the right granulation machine requires careful consideration of material characteristics and production demands. For formulations requiring moisture or liquid binders, a wet granulator provides consistent granule formation with precise control over particle size. In contrast, a dry granulator offers an efficient solution for moisture-sensitive materials, compacting powders into granules without solvents. You can select a solution that ensures reliable performance and meets your production requirements by evaluating these features alongside throughput and cleaning efficiency.
- Precise granulation with liquid binders
- Fast wet granulation for dense particles
- Ideal for pharmaceutical wet mixing
- Integrated drying and granulating in one step
- Consistent granule size with uniform moisture control
- Advanced wet granulation for heat-sensitive materials
- High-speed wet granulation with quick blending
- Uniform particles for better tablet formation
- Efficient granulating process for wet formulations
- Gentle wet granulation with controlled rotation
- Perfect for fine powder-to-granule conversion
- Effective moisture management during granulation
- Dry granulation for moisture-sensitive materials
- Compact powder into uniform granules without binders
- Ideal for dense and durable granule formation
- Smooth dry granulation for fine powders
- Versatile for batch or continuous dry processing
- Minimal heat impact during granule production
Granulator Machine Technical Parameters
| Type | Processing Capacity (kg/h) | Power (kW) | Speed (rpm) | Particle Size Range (mm) | Suitable Material |
|---|---|---|---|---|---|
| High Shear Granulator | 50–500 | 5–75 | 100–1500 | 0.2–3.0 | Wet mixing of powders and binders |
| Fluidized Bed Granulator | 30–300 | 10–60 | 200–1200 | 0.1–2.5 | Wet granules requiring simultaneous drying |
| High-Speed Mixer Granulator | 100–1000 | 15–90 | 300–1800 | 0.3–4.0 | Wet granulation and mixing |
| Pan Granulator | 20–200 | 2–15 | 20–60 | 1.0–5.0 | Wet granulation of fine powders |
| Roll Compactor (Dry Granulator) | 50–800 | 5–50 | 10–30 | 0.5–5.0 | Moisture-sensitive powders |
| Oscillating Granulator | 40–500 | 3–20 | 60–300 | 0.5–4.0 | Dry granulation for fine powders |
Granulator Machine Workflow for Different Types
High Shear Granulator
- Preparation and Setup
- Clean the mixing bowl, impellers, and choppers of the Granulator Machine thoroughly.
- Load dry powders and liquid binders into the bowl.
- Parameter Configuration
- Set impeller speed (100–1500 rpm) and chopper speed based on the required granulation size.
- Adjust binder flow rate and granulation time for optimal performance of the Granulator Machine.
- Granulation Process
- Start the impeller to mix powders.
- Add liquid binders gradually while the chopper ensures even distribution and lump breakdown.
- Monitor granule size and stop when the desired consistency is achieved.
- Post-Granulation
- Discharge granules into a tray for drying.
- Clean all parts of the Granulator Machine using CIP or manual methods.
Fluidized Bed Granulator
- Preparation and Setup
- Ensure the chamber and filters of the Granulator Machine are clean.
- Load dry powders into the granulation chamber.
- Parameter Configuration
- Configure air velocity, inlet temperature, and spray nozzle settings.
- Set granulation and drying times for consistent operation of the Granulator Machine.
- Granulation and Drying Process
- Start airflow to fluidize the powders.
- Spray liquid binder evenly while monitoring particle size.
- Gradually increase air temperature to dry granules efficiently.
- Post-Granulation
- Cool the chamber before discharging granules.
- Clean filters, nozzles, and the chamber thoroughly to maintain the Granulator Machine.
High-Speed Mixer Granulator
- Preparation and Setup
- Inspect and clean the mixing bowl and blades of the Granulator Machine.
- Load powders evenly into the bowl.
- Parameter Configuration
- Set blade rotation speed (300–1800 rpm) and binder addition rate.
- Adjust chopper speed for precise granule size control in the Granulator Machine.
- Granulation Process
- Start the high-speed mixing motion.
- Slowly introduce the liquid binder for uniform granule formation.
- Monitor the particle size during operation to ensure consistent performance.
- Post-Granulation
- Discharge granules and clean all components of the Granulator Machine thoroughly.
Pan Granulator
- Preparation and Setup
- Clean the pan surface of the Granulator Machine thoroughly.
- Load fine powders into the rotating pan.
- Parameter Configuration
- Set pan speed (20–60 rpm) and adjust the tilt angle.
- Configure spray nozzle flow rate for binder addition.
- Granulation Process
- Begin pan rotation and spray liquid binder evenly.
- Allow powders to agglomerate into granules within the Granulator Machine.
- Monitor the granule size for consistency.
- Post-Granulation
- Discharge granules from the pan.
- Clean the pan surface and nozzles manually to prepare the Granulator Machine for the next batch.
Roll Compactor
- Preparation and Setup
- Inspect and clean the rollers and feeding system.
- Load dry powders into the hopper.
- Parameter Configuration
- Set roller pressure, compaction force, and feeding speed.
- Adjust crushing and sieving systems for granule size control.
- Granulation Process
- Guide powders into compaction rollers.
- Compact powders into ribbons, then break them into granules.
- Sieve granules to achieve uniform particle size.
- Post-Granulation
- Collect granules and clean rollers, sieves, and feeding components.
Oscillating Granulator
- Preparation and Setup
- Inspect and clean the rollers and feeding system of the Granulator Machine.
- Load dry powders into the hopper.
- Parameter Configuration
- Set roller pressure, compaction force, and feeding speed.
- Adjust crushing and sieving systems for granule size control.
- Granulation Process
- Guide powders into compaction rollers of the Granulator Machine.
- Compact powders into ribbons, then break them into granules.
- Sieve granules to achieve uniform particle size.
- Post-Granulation
- Collect granules and clean rollers, sieves, and feeding components thoroughly to maintain the Granulator Machine.
Frequently Asked Questions
A granulation machine is used to convert powders into granules, ensuring consistent size, improved flowability, and better compressibility for tablets or capsules. It plays a critical role in pharmaceutical production by enhancing product uniformity and quality.
A wet granulator uses liquid binders to form granules, making it ideal for materials that require moisture for particle agglomeration. A dry granulator, such as a roller compactor pharmaceutical system, compacts powders into granules without using any liquid, making it suitable for moisture-sensitive materials.
A roller compactor pharmaceutical machine compresses powders into ribbons under high pressure, which are then broken into granules. This type of granulation machine is commonly used for dry granulation processes, ensuring uniform granules for further processing.
When selecting a granulation machine, consider the material properties (e.g., moisture sensitivity), desired granule size, production volume, and whether wet or dry granulation is required. Equipment features like speed, capacity, and ease of cleaning are also critical.
Some wet granulators are designed with gentle mixing mechanisms and controlled temperature systems, allowing them to process heat-sensitive materials effectively during granulation.
Regular maintenance of a granulation machine includes cleaning all contact parts, inspecting components like rollers or choppers for wear, and calibrating the system to ensure consistent performance. Proper upkeep is essential for reliable operation in both wet and dry granulation processes.